No.13 November 2018

Cardiometric control & monitoring in therapy: instrument for treatment correction

Assessment of therapy quality

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• Dear readers!

  Our Journal’s quest for scientific frontiers leads to publications on hot topics in research, and the current Journal issue is supporting this general rule. Following this way, we are presenting hereby one of the hottest themes: Cardiology in Oncology. In this connection, it should be mentioned that it has been just Cardiometry that has been capable of assessing toxicity actions and effects produced both by a malignant tumor and anticancer therapy on the human hemodynamics and the cardiac muscle metabolic processes using the most advanced noninvasive Cardiocode device & technology. The pilot studies associated with these challenging research topics have been conducted by Russian researchers at the Rostov Research Institute of Oncology, Rostov-on-Don, Russia.

• Review

  Cardiotoxicity: a challenge for modern oncology

  Oleg I. Kit, Elena M. Frantsiyants, Elena A. Dzhenkova, Oksana V. Katelnitskaya, Alla I. Shikhlyarova, Aleksandr B. Sagakyants, Ekaterina V. Verenikina, Yuriy А. Gevorkyan, Yuriy А. Fomenko, Vladimir S. Trifanov, Aleksey N. Shevchenko

  The article provides a modern vision of the problem of cardiotoxicity in oncology. Integrity and generality of nodal pathogenetic events in the body in case of carcinogenesis, antitumor therapy and cardiopathology are caused by similar mechanisms at different hierarchical levels. Identity of potential risk factors, including inflammation, aging, obesity, diabetes and smoking, has been noted.

   Cardiotoxicity  Cardiopathology  Carcinogenesis  Trastuzumab  Tissue homeostasis  Antitumor effect

• Original research

  The prospects for applications of cardiometric approach in evaluation of cardiotoxicity under Anthracyclines therapy in patients with breast cancer

  Alla I. Shikhlyarova, Lyubov Y. Vladimirova, Natalia М. Tikhanovskaya, Yulia Y. Arapova, Tatiana P. Protasova, Elena А. Sycheva, Lyudmila А. Ryadinskaya, Aza А. Lyanova, Irina L. Popova, Natalia А. Abramova, Kristina А. Novoselova, Anna E. Storozhakova, Maria О. Ezhova, Yuliana S. Shatova, Aleksandr E. Lisutin, Viktoria V. Pozdnyakova, Irina R. Dashkova, Stella M. Babieva

  The aim is to study the action and effects of antitumor polychemotherapy (PCT) with Anthracyclines on the cardiovascular system performance in primary oncological patients with breast cancer (BC).

   Cardiotoxicity  Chemotherapy  Anthracyclines  Breast cancer  Cardiometric approach  ECG  Myocardial metabolism  Baevsky index

• Report

  Motion of blood formed elements in a pulsatile hemodynamic flow

  Vladimir I. Timoshenko, Nikolay N. Chernov

  This paper offers some results obtained in our studies on the motion of individual formed elements in blood with due regard of a pulsatile flow of the plasma in the blood vessels. An analysis of the process of the motion of the blood particles having different shapes in a pressure wave variable field of the pressure wave has been completed herein.

   Blood formed elements  Motion  Pressure wave variable field  Human circulatory system  Physical models of motion of formed elements

• Original research

  Actions and effects of malignant tumor growth and chronic neurogenic pain exerted on the glutathione system in cardiac mitochondria in experimental animals

  Irina V. Neskubina, Elena М. Frantsiyants, Ekaterina I. Surikova, Irina V. Kaplieva, Lyubov К. Trepitaki, Lyudmila А. Nemashkalova, Yulia A. Pogorelova, Alla I. Shikhlyarova, Galina V. Zhukova, Pavel N. Anistratov, Viktoria L. Volkova, Natalia А. Chertova, Oksana Е. Zhenilo, Anna А. Cherkasova, Olga G. Selezneva

  The aim hereof is to study the glutathione system peculiarities in the cardiac mitochondria in experimental animals against the background of a tumor process, chronic pain and the combined effect both of chronic pain and the tumor process.

   Cardiac mitochondria  Experimental melanoma В16/F10  Chronic neurogenic pain  Mice  Glutathione system

• Essay

  Cardiometry in oncology: new digital possibilities for analyzing the cardiovascular system state in cancer patients

  Alla I. Shikhlyarova, Mikhail Y. Rudenko, Vladimir А. Zernov, Elena М. Frantsiyants, Elena А. Dzhenkova, Lyubov Y. Vladimirova, Lyudmila Y. Rozenko, Dmitriy A. Rozenko, Nailya К. Guskova, Larisa N. Vaschenko, Yulia Y. Arapova, Tatiana P. Protasova, Elena А. Shirnina, Tatiana А. Barteneva, Marina А. Gusareva, Vitaly I. Voshedsky, Inna V. Pavlyatenko

  The new high-tech era begins not with supply of an innovative product to the market, but rather with an intellectual leap in the field of open issues in fundamental engineering, healthcare and education. In the present essay, an example of the successful translation of mathematical, physics- and engineering-related philosophy into the digital platform of Cardiometry is discussed. The theory of hemodynamics, the laws of axiomatics, logic and adaptation can be expressed in terms of mathematics. The original analytical software used in PC-assisted device Cardiocode allows carrying out a phase analysis of the hemodynamics within an extended range.

   Cardiometry  Oncology  Hemodynamics  Cardiometric approach  Cardiotoxicity pathogenesis  Prediction  ECG  Rheogram  Metabolic parameters  The Baevsky stress index

• Original research

  Effect of slow coronary flow on signal-averaged electrocardiogram

  Hossein Nough, Elahe Rafiei khoshnood, Aryan Naghedi, Leila Hadiani, Mohammad Vahid Jorat

  The slow flow coronary or decreased coronary TIMI flow rate is characterized by delayed pacification of coronary vessels in the absence of any evidence of obstruction coronary artery disease and is detected by coronary angiography. In the present study, we aimed to evaluate the effects of slow coronary artery flow on signal-averaged electrocardiogram (SAECG) as a possible indicator of increased risk for ventricular arrhythmias and sudden cardiac death.

   Late potential  Slow coronary flow  Signalaveraged electrocardiogram  Sudden cardiac death  Ventricular arrhythmias

• Original research

  The state of free-radicals procceses in cardiomyocytes in rats under the action of Doxorubicin and protection by Preductal

  Oleg I. Kit, Elena M. Frantsiyants, Irina V. Neskubina, Ekaterina I. Surikova, Elena V. Shalashnaya, Lyudmila A. Nemashkalova, Natalia D. Cheryarina, Olga V. Kozyuk, Yulia A. Pogorelova, Larisa S. Kozlova, Valeria A. Bandovkina, Irina V. Kaplieva, Lidia K. Trepitaki, Roman E. Myagkov, Mikhail А. Kozhushko, Sergey V. Sanamyants, Mikhail А. Averkin, Roman Е. Tolmakh

  The aim of our research work was to investigate the state of the lipid peroxidation system – the antioxidant protection system (LPO-AOS) in heart tissue in rats received either Doxorubicin alone or in combination with Preductal premedication.

   Сardiomyocyte  Doxorubicin  Preductal  Lipid peroxidation  Antioxidant protection

• Original research

  Assessment of the efficacy of a peroral anticoagulant after surgical resection of gastric cancer

  Oksana V. Katelnitskaya, Oleg I. Kit, Igor I. Katelnitsky, Maksim N. Duritsky, Nailya K. Guskova, Petr N. Gabrichidze, Viktoria R. Zakharchenko, Aleksandr V. Snezhko, Yuriy А. Przhedetskiy, Sergey I. Poluektov, Alla V. Pustovalova

  Patients suffering from gastric cancer have a high risk of postoperative thrombotic complications and often use anticoagulants. Direct oral anticoagulants absorb in the proximal region of the digestive tract. Consequently, a reduction in anticoagulating activity is possible. In the present research given is an evaluation of the anti-Xa activity upon administration of Rivaroxaban at a fixed dose of 20 mg once daily in oncological patients after gastrectomy or cases of extensive resection of the stomach.

   Gastrectomy  AntiXA activity  Rivaroxaban  Vein thrombosis

• Report

  Functional state of the blood coagulation system in postsurgery period in patients with malignant tumors of the GI tract

  Oksana V. Katelnitskaya, Oleg I. Kit, Nailya K. Guskova, Kristina А. Avanesova, Igor I. Katelnitsky, Dmitry S. Petrov, Aleksandr V. Shaposhnikov, Sergey N. Dimitriadi, Anna V. Chubaryan, Dmitry V. Burtsev, Yulia N. Krokhmal, Ekaterina О. Vasilieva

  The present paper analyzes changes in coagulation system markers in 64 patients with malignant tumors of the GI in surgical treatment. Results obtained when using parameters of the expanded coagulogram and a new global hemostatic assessment test with the use of Thrombodynamics recorder T2 have been evaluated. Based on the findings, we have developed models for predicting postoperative venous thrombosis and compared different methods for the coagulation system examinations.

   Hemostasis system  Thrombinemia  Thrombodynamics  Gastric cancer  Colon cancer

• Original research

  The state of hydrolytic processes in the myocardium and its draining lymphocytes in rats under the effect of Doxorubicin under protective Trimetazidine premedication

  Elena М. Frantsiyants, Ekaterina I. Surikova, Irina V. Kaplieva, Lidia K. Trepitaki, Irina V. Neskubina, Elena V. Shalashnaya, Valeria A. Bandovkina, Larisa S. Kozlova, Yulia A. Pogorelova, Lyudmila A. Nemashkalova, Natalia D. Cheryarina, Irina S. Tavaryan, Olga V. Kozyuk, Lyudmila Y. Rozenko, Pavel G. Sakun, Vladimir S. Trifanov

  The aim hereof is to study the activity of cathepsin D (CatD), alkaline phosphatase (ALP) and acid phosphatase (AP), the antitryptic activity (ATA) of acid-stable inhibitors (ASI) in rats in heart tissue and its draining lymphocytes under introduction of Doxorubicin and protection with Trimetazidine.

   Cardiotoxicity  Doxorubicin  Trimetazidine  Cathepsin D  Acid phosphatase  Alkaline phosphatase

• Original research

  Disorders of the cardiovascular system performance in the early post-castration period in patients with locally advanced cervical cancer and their correction with the low-dose xenon therapy

  Alla I. Shikhlyarova , Natalia N. Popova, Anna P. Menshenina, Yulia Y. Arapova, Tatiana P. Protasova, Andrey А. Korobov, Andrey V. Yakushin, Larisa N. Vaschenko, Dmitry А. Burtsev, Olga V. Khokhlova, Viktoria Y. Przhedetskaya, Viktoria А. Ivanova

  The aim hereof is to study the cardiovascular system disorders in the early post-castration period in patients with locally advanced cervical cancer and a possibility of correction of such disorders with the low-dose xenon therapy.

   Locally advanced cervical cancer  Postovariectomy syndrome  Xenon therapy  Electrocardiogram  Myocardial metabolism  Baevsky adaptive tension index

• Case report

  Ruptured mycotic hepatic artery aneurysm associated with methicillin sensitive staphylococcal endocarditis

  Hamidreza Varastehravan, Hasan Salmanroghani, Aryan Naghedi

  Hemobilia is a rare cause of upper gastrointestinal hemorrhage. Classical presentations of hemobilia are biliary colic, jaundice, hematochezia and melena. Persistent bleeding sometimes requires urgent therapeutic intervention, such as angiographic intervention or surgery. It may be secondary to trauma, inflammatory disorders, gallstones or tumors. Hepatic artery aneurysm rupture is a rare cause of gastrointestinal bleeding.

   Hemobilia  Hepatic  Mycotic  Aneurysm  Bacterial endocarditis  Aortic valve replacement  Mitral valve replacement  Coil embolization

• Original research

  Features of the psychosomatic state in lung cancer patients and psychopathophysiological aspects of cardiovascular diseases

  Galina V. Zhukova, Alla I. Shikhlyarova, Natalia М. Maschenko, Elena А. Shirnina, Mikhail S. Zinkovich, Tamara G. Airapetova, Pavel А. Anistratov, Lyudmila Y. Rozenko, Larisa N. Vaschenko, Dmitry V. Burtsev, Marina А. Gusareva, Olga V. Kozyuk, Aleksey N. Shevchenko

  The aim hereof is a comprehensive study of the mental, adaptive and hormonal status in patients with lung cancer with varying prevalence of the malignant process. The obtained results are compared with data on the psychosomatic state and subclinical disorders in the thyroid system in patients with cardiovascular diseases.

   Lung tumors  General nonspecific adaptation reactions of the organism  Euphoric reaction  Depression  Thyroxine  Cardiovascular diseases

• Short report

  A brief analysis of the use of non-linear time-frequency filtering for processing ECG signals

  Yeldos A. Altay, Artem S. Kremlev

  Some current trends of the use of non-linear time-frequency filtering approach to ECG signal processing are discussed herein. A brief review of an application potentiality of non-linear filtration is offered for long-term ECG signal processing. Possible problems of long-term monitoring, related to measurements interference and noise of ECG signal, are revealed. To eliminate the revealed problems, in further research, an implementation of a processing system using the non-linear-threshold time-frequency filtering method is planned. It is expected to improve an accuracy of cardiac data processing considering features of interference and measurement noise of different intensity.

   ECG signal  Physiological noise  Timefrequency filtering  Thres­hold filtering  Empirical modes

• Short report

  Metabolic processes evaluation in cardiac muscles on the basis of cardiometry

  Vladimir A. Zernov, Konstantin K. Mamberger, Dmitry F. Makedonsky, Sergey M. Rudenko

  The article briefly discusses the cardiometric approach to the evaluation of metabolic processes in cardiac muscle. Reactions occurring during the various phases of the cardiac cycle, primarily in the QRS complex, are shown. The dynamics of energy processes occurring before and after physical load, as well as the reactions occurring during it, are presented. The ECG derivative is used.

   Metabolic processes  ECG  Cardiac cycle phase  Cardiac muscle  Derivative  Physical load
• American Heart Association (AHA) annual conference

  On November 10-12, 2018, the American Heart Association (AHA) annual conference was held in Chicago (Illinois, USA) The three-day conference was attended by several thousand doctors, developers of medical equipment, entrepreneurs and other experts in the field of cardiology from around the world. The representative of Russia, namely the researcher of the Russian New University Kamyshev K.V., also took an active part therein.