No.17 November 2020

Cardio- and neurophysiology

We are pleased to offer new papers to outline breaking-through research topics in cardio- and neurophysiology

Original research

Intracellular electrophysiological evidence: how pain is experienced by neurons

Valery I. Orlov, Alla I. Shikhlyarova

The aim hereof is to identify changes in the performance of the CNS neurons under the prolonged action of low-threshold pain factor according to indicators of the membrane potential level, parameters of the action potential and the pattern of the firing activity distribution of the neurons.

NeuronCardiomyocyteMembrane potentialFiring rateLow-intensity stimulationPain

Original research

Systematic design of optimized pulse shape for transthoracic defibrillation

Nikolay N. Chernov, Oksana I. Korotkova, Aleksandr A. Bezverkhii

In the study conducted by us previously, it was found that not only the energy of the discharge, but also the amplitude of current, the pulse duration and its shape have their significant influence on the efficacy of defibrillation.

Transthoracic defibrillationBiphasic pulseCurrent stabilizationCardiomyocytes repolarizationVentricular fibrillation

Original research

Influence of urokinase gene knockout on level of prekallikrein and kallikreins 1 and 14 in mice with melanoma growth against the background of pain

Elena М. Frantsiyants, Ekaterina I. Surikova, Valeriya А. Bandovkina, Irina V. Kaplieva, Irina V. Neskubina, Natalia D. Cheryarina, Viktoria V. Pozdnyakova, Oleg I. Kit

The aim is to study the content of prekallikrein, kallikreins 1 and 14 (KLK-1 and KLK-14) in mice under the conditions of activation and inhibition of the B16/F10 inoculated melanoma growth.

MiceUPA knockoutB16/F10 melanomaChronic neurogenic painKallikrein-kinin systemSkinTumor

Review

Prospects for the use of neural networks in cardiometry

Konstantin V. Kamyshev, Viktor M. Kureichik, Ilya M. Borodyanskiy, Evgenie Y. Bersenev

Artificial neural networkECGCardiometry

Short report

Functional state of the cardiovascular system in female students with different academic performance grades

Vaha A. Anzorov, Svetlana V. Moryakina

The work is devoted to the study of the functional state of the cardiovascular system in female students with different academic success.

StudentAcademic performanceHeart rateArterial pressureMinute blood volume

Original research

Estimation of the cardiovascular morbidity in the population of the Kabardino-Balkarian Republic according to the number of visits to health care offices

Aksana M. Kardangusheva, Irina K. Tkhabisimova, Antonina F. Budnik, Inessa Z. Shogenova, Sofiat Kh. Sizhazheva

The aim is to evaluate the level, structure and dynamics of cardiovascular morbidity in the Kabardino-Balkarian Republic for the period from 2014 to 2019.

MorbidityCirculatory system diseasesCerebrovascular diseaseIschemic heart diseaseArterial hypertension

Original research

Anti-tumor, anti-edematous and analgesic effects of transcranial magnetic therapy in complex treatment of brain tumors of a high degree of malignancy

Ivan А. Popov, Alla I. Shikhlyarova, Eduard Е. Rostorguev, Elena М. Frantsiyants, Lyudmila Y. Rozenko, Dmitry Y. Iozefi, Marina А. Gusareva, Galina V. Zhukova, Oleg I. Kit, Marina A. Engibaryan

The results obtained in this study have demonstrated a possibility to increase the efficacy of the complex treatment of patients with brain tumors of a high degree of malignancy with the use of factors of the magnetic-wave nature, including low-intensity PMF and ELF MF, which can be integrated into the adjuvant therapy scope.

GlioblastomasElectromagnetic fieldsApoptosisNeurogenic painAnti-edematous effectCorrection of phsychosomatic and vascular disorders

Original research

Prospects for cardiovascular system telemonitoring in solving tasks in Federal National Project “Generation Seniors”

Mikhail А. Yakushin, Roman V. Gorenkov, Olga G. Dvorina, Sergey Y. Yarotsky

The paper presents an analysis of some promising lines of developing off-office telemonitoring. Some applications of expert systems designed on the basis of algorithms used for medical decision making are discussed herein.

TelemedicineTelemonitoringInformation technologiesOff-office monitoringExpert systemsMedical decision makingGeriatryMedical follow-up

Original research

Approaches to the gene therapeutic correction of the pathogenetic mechanisms of coronary insufficiency

Oleg G. Makeev, Evgeny A. Shuman, Arteom V. Korotkov, Svetlana V. Kostyukova

The absence of neoangiogenesis in the ischemic myocardium is the reason for the widespread prevalence of cardiovascular diseases.

Coronary insufficiencyTherapeutic angiogenesisGrowth factorsGene plasmids

Short report

Methodological foundations for ensuring the stability in training athletes of various kinds of sports

Guriy P. Stupakov, Vladimir A. Zernov, Nina V. Shcherbinina, Nadezhda N. Prudnikova, Stepan K. Mamberger

A unified approach to the problems of health preservation in athletes, taking into account the options for phenotyping their health and basing on the main indicators of homeostatic potential.

Health phenotypingHomeostatic potentialReserve capabilitiesEnergy supplyAdaptation potentialBiomedical effects

Short report

Algorithm for calculating blood pressure (BP) using a spline database of pulse waves

Igor Yavelov, George Danielyan, Ivan Kireev, Andrey Rochagov, Anatoly Zholobov, Oleg Yavelov

Finding an algorithm for determining blood pressure (BP) along the pulse wave contour (PW) is the most difficult task after solving the problem of obtaining the most undistorted PW signal.

Algorithm for determining blood pressure (BP)The contour of PWArterial tonometerSpline base of PW reference standard curve patternsMedical accuracy of blood pressure determination

Original research

Right ventricular echocardiographic predictors of functional capacity in patients with heart failure with reduced ejection fraction

Wael Tawfek, Karim Elakabawi, Hamza M. Kabil, Tarek H. Abo EL Azm, Ahmed Ramzy, Mostafa M. Khalil

Patients with chronic heart failure (CHF) experience marked reduction in their exercise capacity which has detrimental effects on their activities of daily living, health- related quality of life (HRQoL), and ultimately their hospital admission rate and mortality.

Heart failureFunctional capacityEchocardiography

Review

Electrocardiogram frequency characteristics study by processing and analysis of the signal in time domain and spectral domain

Vitaly O. Chereshnev, Sergey G. Proskurin

This paper presents the results of a study in which cardiac signal of the first lead of a standard digital ECG system were processed. By filtering in the time domain, the cardiogram was clarified of noise that reduced influence of spectral harmonics by 10-15%.

Digital electrocardiogramDigital ECG processingECG smoothingSpectral analysis

Original research

Chronic neurogenic pain is responsible for changes in concentrations of biogenic amines in the brain in urokinase knockout mice with melanoma В16/F10

Elena М. Frantsiyants, Valeriya А. Bandovkina, Irina V. Kaplieva, Ekaterina I. Surikova, Irina V. Neskubina, Natalia D. Cheryarina, Viktoria V. Pozdnyakova, Oleg I. Kit

Our aim is to study special features of actions and effects of chronic neurogenic pain on concentrations of biogenic amines in the brain in tumor-bearing urokinase knockout mice (uPA).

С57/В16 mice lineUPABrain biogenic aminesChronic neurogenic painInoculated melanoma В16/F10

Original research

The impact of multiple overlapping new generations drug-eluting stents on six-month clinical outcomes in patients with anterior STEMI treated with primary PCI

Karim Elakabawi, Jiahao Feng, Hameed Ullah, Wael Tawfik, Mohamed Mahrous, Mohamed Salem, Ning Guo, Zuyi Yuan

Implantation of multiple (≥ 2) overlapping stents has been associated with adverse outcomes after percutaneous coronary intervention (PCI).

ST elevation myocardial infarctionPercutaneous coronary interventionDrug-eluting stentsStent overlap

Original research

Effect of smoking on the cardiovascular system of man

Vaha A. Anzorov, Svetlana V. Moryakina

The article presents the state of the cardiovascular system of smokers with different periods of tobacco smoking.

HeartBlood pressureAtrial systoleTime of ventricular excitation

Review

Succinate as a mobilization cue

Eugene I. Maevsky, Anna A. Vasilyeva, Mikhail V. Kozhurin, Paul Leonard, Polina M. Schwarzburd, Mikhail I. Uchitel, Elena A. Zapatrina, Marina E. Maevskaya, Lyudmila A. Bogdanova

Succinic acid, being a metabolite of the Krebs cycle and the end product of anaerobic transformations in mitochondria, functions outside mitochondria and cells as a regulatory signal.

Adaptive succinate gainStabilization HIFSuccinate receptor activation

Cardiometry's library

The books presented further herein are published under the auspices of “The Fund of Outstanding Scientific Discoveries”. The books offer detailed descriptions of theory and practice of the latest scientific discoveries in the field of Physiology and Medicine, which have found a wide application and which make human life better.

Founders of Cardiometry

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