No.16 May 2020

Heart & circulatory system

Natural strengthening of immunity

Physical exercise and naturopathy

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• Dear readers!

  We should mention that Cardiometry is a fine diagnostics tool to assess heart life expectancy. Our experts, using Cardiocode in “red zones” in intensive care units, have confirmed effectiveness of noninvasive measuring of the hemodynamics data on the cardiovascular system performance in critical patients with different severity degrees. The medical staff involved had a possibility not only to monitor the state in each critical patient, but also to predict and control the progression of a disease. We are going to publish some results of this pilot study in our next issues.

• Review

  The metabolism rationale for applying of succinate-based compositions to maintain high performance in a human organism

  Eugene I. Maevsky  Anna A. Vasilieva  Anna A. Vasilieva  Elena V. Grishina  Mikhail L. Uchitel  Lyudmila A. Bogdanova  Mikhail V. Kozhurin 

  Design of an effective succinate-based agent for the use in sports has required a profound analysis of the main action mechanisms of the agent in question. Our paper reflects basic principles, which are decisive for the design of the offered succinate-based agent to increase the organism performance and the rate of recovery after intensive physical loading. We have treated a special role of the metabolic conversions of succinate in energy exchange of mithochondria: high energy efficiency, possibility of beneficial oxidation under oxygen deprivation, anaerobic formation and possible consequences of the above phenomenon.

   Succinate  Metabolism  Succinic acid  Hypoxia

• Original research

  Cardio-oсulometric indicators of psychophysiological readiness of students to examinations

  Vladimir A. Zernov  Elena V. Lobanova   Elvira V. Likhacheva   Lyubov P. Nikolaeva   Diana D. Dymarchuk   Denis S. Yesenin   Nikita V. Mizin   Aleksandr S. Ognev   Mikhail Y. Rudenko   Natalia Y. Galoi   Anna R. Sudarikova

  Cardio-oсulometric indicators to grade psychophysiological readiness of students to examinations are described herein. Given is an experimental evidence that transitions from a low level of psychophysiological readiness of students to examinations to a high level of such readiness thereto is really accompanied by significant changes in the organism performance, first of all, in that of the heart. It is shown that a reliable marker of such changes is the heart rate variability assessment using the Baevsky stress index (SI), as well as the oculometric peculiarities of response to the visual stimuli, which students associate with their upcoming examinations.

   Cardiometry  Heart rate variability  Baevsky stress index  Psychophysiological readiness  Examinations  Unified state examination (USE)  Eyetracking  Stress tolerance  Autonomic coefficient  Total deviation from the LüscherValneffer autogenic norm

• Original research

  Personal profile of systemic hemodynamics in solving global problems of public health

  Mikhail А. Yakushin   Roman V. Gorenkov   Olga G. Dvorina   Sergey Y. Yarotsky   Guzal Shukurlaeva  

  The study of systemic hemodynamics has been conducted in individuals who suffer from arterial hypertension. Regularities of formation of the personal profiles of the systemic hemodynamics have been determined in this category of patients. A fresh method of antihypertensive therapy is offered which is based on establishment of relationship between the personal profile of the systemic hemodynamics and the hemodynamic drug effect. The clinical effectiveness of the proposed method has been proven.

   Arterial hypertension  Metabolic syndrome  Systemic hemodynamics  Antihypertensive therapy  Volume compression oscillometry

• Original Research

  The importance of the study of central hemodynamics using volumetric compression oscillometry in clinical practice: resolved and unresolved issues

  Roman V. Gorenkov^1,2   Mikhail A. Yakushin^1,3   Diana E. Safina³   Olga G. Dvorina³   Sergey A. Orlov²   Natalia P. Сhernus²  

  The article discusses the promising possibilities of using the method of volumetric compression oscillometry in clinical practice, which allows to simultaneously determining 20 indicators of central hemodynamics. A comparative analysis with other research methods is presented herein, and the advantages of the presented method in the diagnostics of cardiovascular diseases are shown. The problematic issues in using this method and ways to solve them are considered herein.

   Central hemodynamics  Volumetric compression oscillometry  Cardiovascular diseases  Arterial hypertension

• Original research

  Cardiometric evidence data on human self-control of emotional states in the context of the use of metaphoric associative cards

  Vladimir A. Zernov   Elena V. Lobanova   Elvira V. Likhacheva   Lyubov P. Nikolaeva   Diana D. Dymarchuk   Denis S. Yesenin   Nikita V. Mizin   Aleksandr S. Ognev   Mikhail Y. Rudenko   Natalia Y. Galoi   Anna R. Sudarikova

  The paper presents our experimental evidence of validity of our hypothesis that definite, substantively different, psychophysiological states of a human individual can be really fixed with the use of metaphoric associative cards, and that transitions from one psychophysiological state to another are accompanied by significant changes in the performance of the human organism, and, first of all, in the performance of the heart.

   Cardiometry  Heart rate variability  Baevsky stress index  Emotional state  Validity  Coaching associative cards  Metaphoric associative cards  Psychocorrection  Psychotherapy  Psychological consultation  Stress  Subjective genesis  Supra situational activity  Psychosomatic selfregulation

• Original research

  Assessment of system-related hemodynamics and tissue hydration in female patients with preeclampsia

  Nikolay N. Chernov   Aleksandr A. Bezverkhii

  Hypertension disorders are reported to cover up to 10% of pregnancies in the world. It is precisely the arterial hypertension that is the leading cause of developing serious complications, long-term invalidation and high maternal and infant mortality rates. In the context of the maternal mortality, preeclampsia may be attributed to 25% of all lethal outcomes. Preeclampsia occupies the second place in the maternal mortality structure. Multifetal pregnancy is a risk factor for developing of preeclampsia.

   Preeclampsia  Hemodynamics  Tissue hydration  Intraabdominal hypertension  Arterial hypertension  Multifetal pregnancy

• Original research

  Signal morphological criteria for cardiotoxicity in breast cancer chemotherapy

  Alla I. Shikhlyarova   Elena M. Frantsiyants   Lyubov Y. Vladimirova   Anna E. Storozhakova   Larisa N. Vashchenko   Emma E. Kechedzhieva   Galina V. Zhukova   Elena A. Sheyko

  A high incidence of breast cancer is observed in all countries throughout the world, and this dictates the use of aggressive antitumor drugs. The toxogenic effect of anthracycline drugs on the cardiovascular system under conditions of oncological pathology determines the need to expand the diagnostic capabilities for detecting cardiotoxicity, including searching for signal morphological markers in blood serum. The aim of this work is to study the structure of solid-state films of blood serum in patients with breast cancer at the stages of their chemotherapeutic treatment to identify signal criteria for cardiotoxicity.

   Breast cancer  Anthracyclines  Cardiotoxicity  Blood serum morphology

• Report

  The study of hemodynamics in critical patients under intensive care unit conditions

  David М. Tamrazyan   Alla I. Shikhlyarova   Oleg N. Kopylov   Olga G. Pyagai

  Studies of hemodynamics in critical patients under intensive care unit conditions have been a very difficult task until now [1]. There are a number of reasons for that. No instruments capable of noninvasively recording data on hemodynamics and metabolism, as well as the cardiovascular system performance, could be used.

   Hemodynamics  Resuscitation  ECG

• Original research

  Evaluation of general repolarization of cardiomyocites with biphasic pulses of different shapes

  Nikolay N. Chernov   Aleksandr A. Bezverkhii   Vladimir I. Timoshenko

  The paper presents an analysis of advanced shapes of biphasic pulses, which have found a widespread application and have been clinically tested. The aim is to study the main parameters of the impact of different shapes of the existing pulses and their due consideration in a development of a defibrillator.

   Biphasic pulse  Defibrillation  Cardiomyocytes repolarization  Ventricular fibrillation  Currentcontrolled defibrillation

• Original research

  Polynomial filtering of low- and high- frequency noise for improving the accuracy of ECG signal processing: new advancements

  Yeldos A. Altay   Artem S. Kremlev

  The article describes a solution of the ECG signal processing problem in the presence of low- and high- frequency noises, which reduce the accuracy of selection of the signal informative parameters during their processing. To increase the accuracy of the signal informative parameters selection, developed is a new method for noise filtering based on a polynomial approximation of high frequency filters and wide-band reject filters using Newton polynomials.

   ECG signal processing  Filtering  Highfrequency filter  Reject filter  Cascade of filters  Lowfrequency noise  Highfrequency noise  Newton polynomial  Noise attenuation  Measuring electrodes

• Original research

  Review of the recommender systems application in cardiology

  Konstantin V. Kamyshev   Viktor M. Kureichik   Ilya M. Borodyanskiy

  The article provides a review of the recommender systems application in medical field, cardiology, in particular. The concept of recommender systems is defined, the brief history of the recommender systems development is given. The main types of recommender systems and principles of their construction are presented. The advantages and disadvantages of the recommender system methods application in cardiology are identified. Methods for improving the recommender systems are proposed.

   Recommender system  Filtering  Collaborative  Content  Hybrid  Information retrieval  MRS  PEHC

• Report

  Effects produced by electrode characteristics on the accuracy of formation of electrical cardiac signal parameters

  Yeldos A. Altay   Artem S. Kremlev   Sergei M. Vlasov   Alexey A. Margun   Konstantin A. Zimenko

  Our results of analyzing effects made by electrode characteristics on the accuracy of the ECG signal parameters formation are presented herein. Analyzed is a correlation between the measured characteristics of the electrodes and a probability value that determines accuracy of the ECG signal parameters formation. With the help of scatter plots demonstrated is the strength of the correlation between the assessed variables. Our analysis of the obtained results shows that the harder is the contact agent in an electrode, the more accurate are the formed ECG signal parameters.

   Algorithm of ECG signal processing  Statistical processing  Correlation analysis  Scatter plot  Measuring electrodes  ECG signal accuracy  ECG signal recording

• Original research

  Rose Angina Score can really estimate myocardial perfusion scan results in both diabetic and non-diabetic patients?

  Nasim Namiranian   Aryan Naghedi   Narges Soltani   Reza Nafisi Moghadam   Amir Pasha Amel Shahbaz   Seid Kazem Razavi-Ratki

  Cardiovascular diseases are among the most important causes of mortality and morbidity worldwide. There are different risk factors explained for cardiovascular diseases and diabetes mellitus (DM) is notable among them. There are different modalities for diagnosis and risk assessment of cardiovascular diseases such as myocardial perfusion imaging (MPI) but considering high price and low accessibility of this modality we decided to assess any possible association between MPI findings and Rose angina score (RAS) in both diabetic and non-diabetic patients.

   Rose angina score  Rose angina questionnaire  Diabetes mellitus  Myocardial perfusion scan  Cardiovascular disease  Coronary artery disease  Ischemia

• Original research

  Effects produced by automated plasmapheresis on morphofunctional data on cardiovascular system performance in ischemic heart disease patients

  Yury E. Malchevsky   Aligeidar A. Ragimov

  We have performed the study of the effects made by the automated plasmapheresis application on ischemic heart disease clinical manifestations, echocardiographic indices and heart rate variability in patients with exertional angina III-IV functional class. It has been found that the applied plasmapheresis method is capable to reduce the severity of the disease clinical manifestations and improve the echocardiographic characteristics of the heart, in particular, reduce the level of end-diastolic volume, and increase ejection fraction.

   Exertional angina  Plasmapheresis  Echocardiography  Heart rate variability  Holter monitoring