No.3 November 2013

No.3 November 2013

Creation of artificial heart: engineering and ethical issues

The topics of the current issue cover creation of artificial heart: both engineering and ethics. Primarily it should be noted that our idea is to consider these problems not in the context of the latest technological advancements accompanied by a further definition of problems of this sort, but basically by shaping a discussion what research should be performed for this purpose at next stages.

To overcome numerous contradictions in the knowledge of the blood transportation, a hypothesis was supposed asserting the swirling pattern of blood flow in the heart and main vessels which resembles tornado-like flows and which is widespread in nature. These flows can be exhaustively described by the exact solutions of the nonstationary hydrodynamic Navier-Stokes equations and the continuity equations for the class of viscous swirling flows offered by Kiknadze - Krasnov.

Up to the present, ECGs have been classified on the basis of the analysis of the ECG curve shape. But this made impossible to classify many ECG shapes. The most promising methods for the classification must evaluate each of the 10 cardiac cycle phases both by their functions and hemodynamic parameters. The aim hereof is to develop the new classification principles for all possible ECG shape variations.

A cardiac muscle performance assessment in terms of acid-alkaline balance has never been carried out before. The studies show it is possible to evaluate indirectly aerobic, anaerobic and phosphocreatine processes in the cardiac muscle using ECG only. The aim is to study the capabilities of acid-alkaline balance measurement in the cardiac muscle using ECG only, in combination with the heart cycle phase analysis.

A review and a critical analysis of the specialized literature on justification for the measurement equation and an estimation of a methodical error (uncertainty) of the measurement result are presented in the paper, and some prospects for solving of the issue are discussed herein.

Leonardo da Vinci perhaps was the first who paid attention to the energetic efficiency of existence of vortices emerging near sines of Valsalva and defining normal functioning (opening) of aortal valve. However up to now a fundamental problem of defining of mechanisms of mysterious energetic efficiency of functioning of cardio-vascular system (CVS) of blood feeding of the organism is still remaining significantly not solved and this is, for example, one of the main restriction for the creation of artificial heart and corresponding valve systems.

Recipients of ventricular assist devices (VADR) have a higher incidence to develop antibodies (Abs) against human leukocyte antigens (HLA). Non-HLA antibodies like major histocompatibility complex class I-related chain A (MICA) and autoantibodies against angiotensin type 1 receptor (AT1R) and endothelin receptor A (ETAR) are also implicated in the pathogenesis of acute rejection and allograft vasculopathy. We monitored non-HLA- and HLA-Abs in VADR up to one year after implantation.

In the article main principles of ballistocardiography are considered. Special attention is paid to registration of the spatial ballistocardiogramm. There exist two principles of ballistocardiography: dynamic and seismic. In the event of dynamic ballistocardiography body displacements align to an extent with shifting of the general center of body gravity.

There are various indications for a mechanical circulatory support (MCS) devices implantation. We report a case of the use of the MCS in a 39 year old male with acute circulatory collapse and at immediate risk of death after endomyocardial biopsy in order to keep the patient alive until intrinsic cardiac function recovers sufficiently to remove the MCS.

The results of study of an artificial aortic valve by the heart cycle phase analysis are given in the paper. The main aim of the study is identifying the artificial aortic valve influence on cardiovascular system functions, the way and ranges of these functions change. The results of phase blood volume measurement and the numerical values that characterize the metabolic processes in heart muscles are given herein.

To overcome numerous contradictions in the knowledge of the blood transportation, a hypothesis was supposed asserting the swirling pattern of blood flow in the heart and main vessels which resembles tornado-like flows and which is widespread in nature. These flows can be exhaustively described by the exact solutions of the nonstationary hydrodynamic Navier-Stokes equations and the continuity equations for the class of viscous swirling flows offered by Kiknadze - Krasnov.

The "Science, technology, society and Nobel movement" International Nobel Congress (The Tenth International Meeting-Conference) for Nobel Prize Winners and Nobelists devoted to the 180th Anniversary of Alfred Nobel and the 25th Anniversary of the International Information Nobel Center (IINC) took place in Moscow and Tambov (Russia), on 28-31 October 2013.
Our scientific school “Research of cardiovascular system hemodynamics” has been working for more than 10 years at the Russian New University, Moscow, Russia (www.rosnou.ru). As a result, we have created CARDIOMETRY, a fundamentally new scientific field in cardiology.
The ESC 2013 annual congress took place in Amsterdam, the Netherlands. Our journal CARDIOMETRY was represented there for the first time. The journal attracted much attention. A lot of visitors enjoyed the chance to learn more about Cardiometry publications.
The Working Group welcomes suggestions for support and scientific endorsement of consensus documents, standardization reviews, focused seminars and meetings, and professional collaboration and exchange programmes.

CARDIOMETRY’s Library

The books presented further herein are published under the auspices of “The Fund of Outstanding Scientific Discoveries”. The books offer detailed descriptions of theory and practice of the latest scientific discoveries in the field of Physiology and Medicine, which have found a wide application and which make human life better.
Published in 2020. Cardiometry. Fundamentals of Theory and Practice
ISBN 978-5-86746-108-4
A detailed description of the theory is given and the most important criteria for cardiometric diagnostics are presented herein.

Published in 2020. The performance of the cardiovascular system in athletes. Cardiometric characteristics of physical capabilities in athletes’ performance before their sporting activities, in their sporting activities and upon ceasing them.
ISBN 978-5-86746-123-8
This is the first book defining the healthy heart. You can find everything to understand your own physical capabilities.

Published in 2007. Theoretical Principles of Heart Cycle Phase Analysis
ISBN 978-5-86746-125-4 (Russian version)
ISBN 978-3-937909-57-8 (English version)
The book deals with a new fundamental science: cardiometry, which becomes very popular due to its practical applicability.

Published in 2017. Leaflet: The one and only case in history of modern civilization: creating CARDIOMETRY, a new fundamental science. It’s a popular science essay to outline the discovery and the discoverers thereof.

Published in 2019. The paper by Russian mathematicians S.Chefranov and A.Chefranov is devoted to the new analytical solution of the 3D Navier-Stokes equation for compressible medium to clarify the sixth Millennium Prize problem.

Published in 2011. High-accuracy non-invasive measuring of main hemodynamics parameters.
ISBN 978-3-8465-1951-6
The book deals with some new approaches to solutions concerning introduction of a new point on ECG: it’s point L.

Published in 2012. The Cardiovascular System. Physiology, Diagnostics and Clinical Implications.
ISBN 978-953-51-0534-3
You can find four chapters written by the Cardiometry theory originators. One of the chapters treats a problem of measuring AP with a blood pressure cuff and describes the history of the fundamental scientific discovery.

Published in 2016. The Siege of Leningrad. Discoveries in Biology and Medicine.
ISBN 978-5-86746-126-2
The book presents unique data on Physiology in human individuals recorded under the siege of Leningrad during the World War II 1941-1945.

Released in 2004
Certificate of Discovery Registration issued in 1976
Periodic system of human organism states.
ISBN 5-86766-043-6
The periodic system table offers in detail the relevant characteristics of all the five adaptational reactions in a human organism: stress, reaction of training, reactions of calm and elevated activation and over-activation.

Published in 2006. Activation Therapy.
ISBN 5-7507-0179-4
The book provides for a detailed description of all the five adaptational reactions in a human organism: stress, reaction of training, reactions of calm and elevated activation and over-activation. It’s a New Age in health care. The only way to achieve effectiveness in medical treatment is to use the knowledge of the adaptational reactions in a human organism.
Medical equipment designed on the basis of the above mentioned fundamental discoveries
Diagnostics equipment for cardiology: PC-assisted device CARDIOCODE, designed and developed on the basis of the cardiometric technology. It’s an exclusive device capable of delivering unique data within 1 minute for the most accurate cardiovascular system diagnostics.

Unique effective pain- relief and treatment with the use of low-intensity electromagnetic field having some specific ECG wave frequencies: device Ezh-2 (Energy of Life -2). It’s the most efficient and powerful instrument for improvement of the immune system performance. Upon completion of five therapy sessions, the immune system demonstrates a three- or four-fold higher level in its performance.

VIDEO ABOUT CARDIOMETRY

Founders of a new fundamental science: Cardiometry

www.vzernov.com

www.mrudenko.com

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