Chronobiological methods of human body self-regulation reserve evaluation

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Original research

Chronobiological methods of human body self-regulation reserve evaluation

Sergey N. Zaguskin1*Yury E. Gurov1Gina N. Bakuzova2Irina D. Svishcheva2Svetlana N. Zaguskina1

1 Reserch Institute physics of Southern Federal University, 344006, Russia, Rostov-on-Don, Bolshaya Sadovaya st, 105/42
2 Rostov State Medical University, 344022, Russia, Rostov-on-Don, 29 Nahichevansky Lane

* Corresponding author:
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Chronodiagnostical methods for evaluating reserve and unfavourable responses of human cardiac function and under prolonged stress load.

Materials and methods

24-h ECG R–R interval recording of Holter-monitoring ECG recording and 1-h IPI and RespI recordings of healthy young and elderly subjects, post- MI patients, subjects suffered from chronic cerebral ischemia leading to a cognitive decline, healthy subjects following post-stress load, as well as R– R intervals recordings of the AHA ECG database of heart failure and AF. Chronodiagnostics, using non-linear symbolic dynamics method and redundancy quotient of ECG PI, RespI and R– R intervals; differential temperature survey to evaluate cellular immunity; biocontrolled laser therapy.


Self-regulation reserve reduction of oxygen transfer body systems and increase in unfavourable response probability under stress load are accompanied by the amplitude and fluctuation increase of redundancy quotient in the ECG IPI, RespI and R–R intervals, as well as increase of hierarchical desynchronosis with dominating sympathicotonia and vagotonia, decrease in cellular immunity, reduction in rate spectrum of the ECG IPI and R–R intervals.


Symbolic dynamics method provides distinction between age-related and abnormal changes in hierarchy of cardiac rhythms. The amplitude and fluctuation increase of redundancy quotient indicates the increase of control intensity with oxygen transfer body systems and predicts the reduction of self-regulation reserve in cardiac rhythms and unfavourable response probability.


Sergey N. Zaguskin, Yury E. Gurov, Gina N. Bakuzova, Irina D. Svishcheva, Svetlana N. Zaguskina. Chronobiological methods of human body self-regulation reserve evaluation; Cardiometry; No.2; May 2013; p.137-146; DOI: 10.12710/cardiometry.2013.2.137146 Available from:



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