The paper presents the results of the long-term medical & ecological investigations conducted during the experiment Mars-500. Methodology of conducting the long-term medical & ecological investigations and the applied methods are considered.
Monitoring the health of astronauts based on the assessment of the functional state of the body within the realms of norm and pathology. The area of functional states qualifies as the yellow score of health on a notional scale "traffic light of health": Modern medicine is particularly interested in studying the health of the yellow score, because of the preventative measures that could still be taken before making contact with the healthcare system.
Experience of cosmonauts’ health monitoring shows that in the study of healthy subjects clinical approach to the evaluation of various medical and physiological data is almost less effective than the evaluation of organism adaptive abilities. The idea of prenosological diagnosis and the concept of adaptive risks develop in space medicine last years. These new space technologies are being actively tested in terrestrial studies in systems as "home medicine".