The relationship between severity of coronary artery disease and mean platelet volume

Original research

The relationship between severity of coronary artery disease and mean platelet volume

Hamidreza Varastehravan1, Aryan Naghedi1, Hossein Nough1, Hamideh Pourmirafzali1*

1 Shahid Sadoughi University of Medical Sciences
Iran, 97514, Yazd, Jomhuri Blvd

* Corresponding author:
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Increased MPV is a risk factor for cardiovascular diseases and can be associated with coronary artery involvement. In this study, we aimed to investigate the relationship between the severity of coronary artery disease and MPV.

Materials and methods

In this study, a total of 200 patients with coronary artery disease were enrolled. All patients initially underwent coronary angiography. Plasma TG, LDL, and HDL, was measured using commercial kits Integra 800TM. MPV and platelet count was determined by the Sysmex XT-2000iTM. Population were divided into three groups based on the SYNTAX score: low, moderate and high. All angiographic grading of SYNTAX was carried out by two cardiologists with blinded clinical data. After Data collection, these data were entered to SPSS22 software and were analyzed using correlation coefficient regression analysis.


A total of 200 patients entered to the study that 43% and 57 % of patients were female and male, respectively. eighty-seven patients were diabetic and other 113 patients were not diabetic. There was a significant correlation between SYNTAX score and the BMI, hemoglobin, LDL, FBS, EF and particularly MPV. There was no significant correlation between SYNTAX score and systolic and diastolic blood pressure, HDL, triglycerides, WBC and glomerular filtration rate.


The results of this study showed that because of significant correlation between MPV and SYNTAX score, this variable can be used as an indicator of the severity of coronary artery disease.


Hamidreza Varastehravan, Aryan Naghedi, Hossein Nough, Hamideh Pourmirafzali. The relationship between severity of coronary artery disease and mean platelet volume. Cardiometry; Issue 14; May 2019; p.57-63; DOI: 10.12710/cardiometry.2019.14.5763; Available from:


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