Our new tornado-compatible aortic valve prosthesis: notable results of hydrodynamic testing and experimental trials

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Original research

Our new tornado-compatible aortic valve prosthesis: notable results of hydrodynamic testing and experimental trials

Leo A. Bockeria1Andrey V. Agafonov1Gennady I. Kiknadze1Victor O. Kuznetsov1Ivan M. Krestinitch1Shota T. Zhorzholiani1Nadezhda O. Sokalskaya1Alexander Y. Gorodkov1*

1 Bakoulev Scientific Center for Cardiovascular Surgery of the Russian Academy of Medical Sciences, 117931, Russia, Moscow, Leninsky Prospekt 8

* Corresponding author:
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Aims

A shortcoming common to all existing designs of mechanical cardiac valve prostheses is an increased trombogenicity caused, among other factors, by the lack of hydrodynamic compatibility between the luminal part of the prosthesis and the patterned blood flow. The aim of the study is to design and test our new mechanical aortic valve prosthesis to exclude life-long anticoagulation treatment.

Materials and methods

Standard hydrodynamic tests of the new prosthetic valve have been carried out for comparing with the other existing valve designs. A new method for the heart valve prosthesis testing in a tornado-like flow has been developed. The valve function has been verified in a swine excluding the anticoagulation treatment during the period of time exceeding six months.

Results

The significant advantage of the new prosthesis in the standard hydrodynamic tests has been demonstrated. The tests in the tornado-like flow have shown that only this prosthesis allows maintaining the pattern, the head and flow rate characteristics of the tornado-like jet. Upon implanting the new prosthesis in the aortic position in a swine, the good performance of the valve without anticoagulation therapy has been confirmed in the course of more than six months.

Conclusion

Obtained has been the evidence of the merits of the new mechanical aortic valve owing to the due consideration of the hydrodynamic peculiarities of the aortic blood flow and the creation of the design providing the proper hydrodynamic compatibility.

Imprint

Leo A. Bockeria, Andrey V. Agafonov, Gennady I. Kiknadze, Victor O. Kuznetsov, Ivan M. Krestinitch, Shota T. Zhorzholiani, Nadezhda O. Sokalskaya, Alexander Y. Gorodkov. Our new tornado-compatible aortic valve prosthesis: notable results of hydrodynamic testing and experimental trials; Cardiometry; No.4; May 2014; p.31-45; DOI:10.12710/cardiometry.2014.4.3145 Available from: http://www.cardiometry.net/no4-may-2014/aortic-valve-prosthesis

Keywords

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