Our new tornado-compatible aortic valve prosthesis: notable results of hydrodynamic testing and experimental trials

The paper highlights the key stages on the way of a proper understanding of the magnetic field anti-tumor influence mechanisms…

Problems of validation and verification are very critical in medicine. The absence of adequate models describing biophysical processes in the…

It is shown that the mechanism of action of magnetic fields at body level is based on the development of…

Research methodology and methods used in experiment Mars-500 held at the Institute of Biomedical Problems of the Russian Academy of…

Original research

Our new tornado-compatible aortic valve prosthesis: notable results of hydrodynamic testing and experimental trials

Leo A. Bockeria1Andrey V. Agafonov1Gennady I. Kiknadze1Victor O. Kuznetsov1Ivan M. Krestinitch1Shota T. Zhorzholiani1Nadezhda O. Sokalskaya1Alexander Y. Gorodkov1*

1 Bakoulev Scientific Center for Cardiovascular Surgery of the Russian Academy of Medical Sciences, 117931, Russia, Moscow, Leninsky Prospekt 8

* Corresponding author:
   +7 (495) 414-75-78
  This email address is being protected from spambots. You need JavaScript enabled to view it.


A shortcoming common to all existing designs of mechanical cardiac valve prostheses is an increased trombogenicity caused, among other factors, by the lack of hydrodynamic compatibility between the luminal part of the prosthesis and the patterned blood flow. The aim of the study is to design and test our new mechanical aortic valve prosthesis to exclude life-long anticoagulation treatment.

Materials and methods

Standard hydrodynamic tests of the new prosthetic valve have been carried out for comparing with the other existing valve designs. A new method for the heart valve prosthesis testing in a tornado-like flow has been developed. The valve function has been verified in a swine excluding the anticoagulation treatment during the period of time exceeding six months.


The significant advantage of the new prosthesis in the standard hydrodynamic tests has been demonstrated. The tests in the tornado-like flow have shown that only this prosthesis allows maintaining the pattern, the head and flow rate characteristics of the tornado-like jet. Upon implanting the new prosthesis in the aortic position in a swine, the good performance of the valve without anticoagulation therapy has been confirmed in the course of more than six months.


Obtained has been the evidence of the merits of the new mechanical aortic valve owing to the due consideration of the hydrodynamic peculiarities of the aortic blood flow and the creation of the design providing the proper hydrodynamic compatibility.


Leo A. Bockeria, Andrey V. Agafonov, Gennady I. Kiknadze, Victor O. Kuznetsov, Ivan M. Krestinitch, Shota T. Zhorzholiani, Nadezhda O. Sokalskaya, Alexander Y. Gorodkov. Our new tornado-compatible aortic valve prosthesis: notable results of hydrodynamic testing and experimental trials; Cardiometry; No.4; May 2014; p.31-45; DOI:10.12710/cardiometry.2014.4.3145 Available from: http://www.cardiometry.net/no4-may-2014/aortic-valve-prosthesis



Our book in WoS™ Core Collection

We are glad to inform you that the book "Theoretical principles of heart cycle phase analysis" written by researchers from Russian New University has been accepted and indexed in The Book Citation Index in Web of Science™ Core Collection


Founders of a new fundamental science: Cardiometry





Russian New University

Your online partner for English language editing, proofreading, medical writing, formatting, design & development and publication support services

Online ECG / Telemetry Certification Course

Teach you everything you need to interpret arrhythmia and administer a 12-lead EKG

Cardiocode - unique diagnostics of the heart