Identification of non-HLA antibodies in ventricular assist device recipients

The article presents the results of space experiment “Pneumocard”. The investigation involved all 25 Russian members of the ISS crew.…

Consideration is being given herein to some mechanisms of high heart rate variability (high HRV), which cannot be attributed to…

Diagnostic parameter “arterial pressure” known in medical practice from the earliest times is now widely used for assessment of body…

The results of study of an artificial aortic valve by the heart cycle phase analysis are given in the paper.…

Original research

Identification of non-HLA antibodies in ventricular assist device recipients

Sandy von Salisch1Maja-Theresa Dieterlen1Jens Garbade1Sara Klein1Stefan Dhein1Friedrich W. Mohr1Hartmuth B. Bittner2Markus J. Barten1*

1 University Hospital Leipzig, Heart Center, Department for Cardiac Surgery, 04289, Germany, Leipzig, Strümpellstraße 39
2 Florida Hospital Orlando, Department of Cardiothoracic Transplantation and Advanced Cardiac Surgery, 32804, U.S.A., Florida, Orlando, 2415 N Orange Ave Suite 600

* Corresponding author:
   +49 (341) 865-10-21
  This email address is being protected from spambots. You need JavaScript enabled to view it.

Aims

Recipients of ventricular assist devices (VADR) have a higher incidence to develop antibodies (Abs) against human leukocyte antigens (HLA). Non-HLA antibodies like major histocompatibility complex class I-related chain A (MICA) and autoantibodies against angiotensin type 1 receptor (AT1R) and endothelin receptor A (ETAR) are also implicated in the pathogenesis of acute rejection and allograft vasculopathy. We monitored non-HLA- and HLA-Abs in VADR up to one year after implantation.

Materials and methods

Sera of 56 VADR (54.1±12.8 years old, 50 men) were analyzed for Abs against HLA-, MICA-, AT1R- and ETAR several times over one year after implantation using ELISA and Luminex xMAP technology. Blood transfusions, gender and age were reviewed.

Results

Sera of 56 VADR (54.1±12.8 years old, 50 men) were analyzed for Abs against HLA-, MICA-, AT1R- and ETAR several times over one year after implantation using ELISA and Luminex xMAP technology. Blood transfusions, gender and age were reviewed.

Conclusion

Beside HLA- and MICA-Abs, VADR showed high titres of Abs against AT1R or ETAR, which underlines the necessity for monitoring non-HLA antibodies in VADR prior heart transplantation.

Imprint

Sandy von Salisch, Maja-Theresa Dieterlen, Jens Garbade, Sara Klein, Stefan Dhein, Friedrich W. Mohr, Hartmuth B. Bittner, Markus J. Barten. Identification of non-HLA antibodies in ventricular assist device recipients; Cardiometry; No.3; November 2013; p.82-99; DOI:10.12710/cardiometry.2013.3.8299 Available from: www.cardiometry.net/no3-november-2013/identification-of-non-hla-antibodies

Keywords

UPCOMING ISSUE

Our book in WoS™ Core Collection

We are glad to inform you that the book "Theoretical principles of heart cycle phase analysis" written by researchers from Russian New University has been accepted and indexed in The Book Citation Index in Web of Science™ Core Collection

VIDEO ABOUT CARDIOMETRY

Founders of a new fundamental science: Cardiometry

www.vzernov.com

www.mrudenko.com

www.ovoronova.com

OUR PARTNERS

Russian New University


Your online partner for English language editing, proofreading, medical writing, formatting, design & development and publication support services


Online ECG / Telemetry Certification Course

Teach you everything you need to interpret arrhythmia and administer a 12-lead EKG


Cardiocode - unique diagnostics of the heart