Correction of the functional state of female rats after unilateral ovariectomy using a succinate containing composition
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Unilateral ovariectomy (UOE) of female rats caused an increase in duration of the non-reproductive period (NRP) – metestrus and diestrus phases, and shortening of the reproductive period (RP) – proestrus and estrus phases of the estrous cycle (a symptom of hormonal deficiency). Signs of stress persisted 5 weeks after UOE: reduction of the ratio of thymus weight to the weight of adrenal glands (T/A). A two-week course of the succinate-containing composition with added B vitamins (SCCV) administered to the control female rats and those upon UOE has increased the T/A ratio as compared to that of intact animals, which is an indication of “activation” according to Garkavi et al.  and restored the NRP/RP ratio. Cytobiochemical analysis found a significant increase in nitroblue tetrazolium reduction during succinate oxidation in lymphocytes according to reading of animal blood smears.
Anna A. Vasilieva, Maria A. Simonova, Alekber A. Bairamov, Elena V. Grishina, Mikhail L. Uchitel, Eugene I. Maevsky. Сorrection of the functional state of female rats after unilateral ovariectomy using a succinate containing composition; Cardiometry; No.10 May 2017; p.86–92; DOI:10.12710/cardiometry.2017.8692; Available online: www.cardiometry.net/issues/no10-may-2017/ovariectomy-using-succinate