Interrelation between the changes of phase functions of cardiac muscle contraction and biochemical processes as an algorithm for identifying local pathologies in cardiovascular system
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Original research

Interrelation between the changes of phase functions of cardiac muscle contraction and biochemical processes as an algorithm for identifying local pathologies in cardiovascular system

Yury V. Fedosov1*Stanislav N. Zhigalov1Mikhail Y. Rudenko1Olga K. Voronova1Vladimir A. Zernov1

1 Russian New University, 105005, Russia, Moscow, Radio str., 22

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Aims

The interrelation between hemodynamic changes, functions of the cardiovascular system and biochemical reactions in the cells of the heart muscle is investigated in the present paper.

Materials and methods

Several methods were used to influence the metabolism processes in the myocardium. The changes in the phase functions of contraction of different cardiac muscles were recorded. In order to have comprehensive influence on the metabolism processes, normalization of the acid-base balance was performed. L-carnitine and octolipen were used to affect the lipid metabolism.

Results

Phase blood volumes that are characteristic of hemodynamics changed in the course of treatment to reach their nornal values. The ECG shape during the heart cycle phases also changed to reach the norm. The initial ECG shape describing Brugada syndrome almost reached its normal value. Extrasystole disappeared therewith.

Conclusion

The method of the heart cycle phase analysis enables monitoring any changes in hemodynamics and functions of the cardiovascular system. The method can be used for identifying the original cause of pathologies and efficient monitoring of the treatment progress.

Imprint

Yury V. Fedosov, Stanislav N. Zhigalov, Mikhail Y. Rudenko, Olga K. Voronova, Vladimir A. Zernov. Interrelation between the changes of phase functions of cardiac muscle contraction and biochemical processes as an algorithm for identifying local pathologies in cardiovascular system; Cardiometry; No.1; November 2012; p.87-101; DOI:10.12710/cardiometry.2012.1.86100 Available from: http://www.cardiometry.net/issues/no1-november-2012/interrelation-between-the-changes-of-phase-functions

Keywords