Disorders of the cardiovascular system performance in the early post-castration period in patients with locally advanced cervical cancer and their correction with the low-dose xenon therapy

Original research

Disorders of the cardiovascular system performance in the early post-castration period in patients with locally advanced cervical cancer and their correction with the low-dose xenon therapy

Alla I. Shikhlyarova 1*, Natalia N. Popova1, Anna P. Menshenina1, Yulia Y. Arapova1, Tatiana P. Protasova1, Andrey А. Korobov1, Andrey V. Yakushin1, Larisa N. Vaschenko1, Dmitry А. Burtsev1, Olga V. Khokhlova1, Viktoria Y. Przhedetskaya1, Viktoria А. Ivanova1

1 Rostov Research Institute of Oncology, Ministry of Healthcare of the Russian Federation
Russia, 344037, Rostov-on-Don, 14th Line st. 63

* Corresponding author:
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Aims

The aim hereof is to study the cardiovascular system disorders in the early post-castration period in patients with locally advanced cervical cancer and a possibility of correction of such disorders with the low-dose xenon therapy.

Materials and methods

The study involved 28 female patients of reproductive age (49.8 ± 0.5 years) diagnosed with locally advanced cervical cancer. The main test group consisted of 16 patients, who received the xenon therapy in addition to the main treatment in the early post-castration period. The reference group included 12 female patients without xenon therapy. The cardiovascular system functional state was evaluated with cardiac analyzer Cardiocode at three stages: before surgical intervention, on postsurgery day 3 and upon the completion of the therapy.

Results and conclusions

Early manifestations of the post-ovariectomy syndrome in the postsurgery period in female patients with locally advanced cervical cancer were accompanied by a disorder in the cardiovascular bio-adaptive and metabolic regulatory mechanisms of the uncompensated distress type, an excess of the phosphocreatine concentration and a decrease in the oxygen level in the myocardium. Upon the completion of the therapy in the reference group patients, changes in the coronary vessels hemodynamics, the dominance of the anaerobic energy exchange in the myocardium, pronounced neurovegetative and psychoemotional disorders have been revealed. The use of the low-dose xenon therapy in the main test group patients has contributed to normalization of myocardial metabolism, recovery of the aerobic energy exchange, and neutralization of neurovegetative and psychoemotional manifestations of the post-ovariectomy syndrome. Thus, the diagnostics of cardiovascular disorders in the early postsurgery period as well as the correction of the disorders and abnormalities with the low-dose xenon therapy are of great importance in the prevention of cardiovascular diseases in oncogynecologic patients with the post-ovariectomy syndrome.

Imprint

Alla I. Shikhlyarova , Natalia N. Popova, Anna P. Menshenina, Yulia Y. Arapova, Tatiana P. Protasova, Andrey А. Korobov, Andrey V. Yakushin, Larisa N. Vaschenko, Dmitry А. Burtsev, Olga V. Khokhlova, Viktoria Y. Przhedetskaya, Viktoria А. Ivanova. Assessment of the efficacy of a peroral anticoagulant after surgical resection of gastric cancer. Cardiometry; Issue 13; November 2018; p.75-80; DOI: 10.12710/cardiometry.2018.13.7580; Available from: http://www.cardiometry.net/ issues/no13-november-2018/low-dose-xenon-therapy

Keywords

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