Hartmuth B. Bittner

Research methodology and methods used in experiment Mars-500 held at the Institute of Biomedical Problems of the Russian Academy of…

This paper deals with a study of central hemodynamics in 363 pediatric patients with burn shock as compared with a…

Hypertrophic cardiomyopathy (HCM) is the commonest inherited cardio-myopathy. Prevalence 1/500 individuals. The disease has variable expressivity and penetrance, which leads…

The article aims at describing the theoretical principles of cardiometry as a fundamentally new scientific field which enables the accurate…

Hartmuth B. Bittner

Recipients of ventricular assist devices (VADR) have a higher incidence to develop antibodies (Abs) against human leukocyte antigens (HLA). Non-HLA antibodies like major histocompatibility complex class I-related chain A (MICA) and autoantibodies against angiotensin type 1 receptor (AT1R) and endothelin receptor A (ETAR) are also implicated in the pathogenesis of acute rejection and allograft vasculopathy. We monitored non-HLA- and HLA-Abs in VADR up to one year after implantation.

Cardiac allograft vasculopathy (CAV) accounts for major morbidity and mortality late in the heart transplant (HTx) history. The role of antibodies (Abs) directed against human leukocyte antigens (HLA) and non-HLA antigens in the pathogenesis of CAV are still under investigation.

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