Anna G. Chernikova

A shortcoming common to all existing designs of mechanical cardiac valve prostheses is an increased trombogenicity caused, among other factors,…

For a long time cardiologists have not been able to explain why the problem of cardiac arrhythmia in a heart…

Recipients of ventricular assist devices (VADR) have a higher incidence to develop antibodies (Abs) against human leukocyte antigens (HLA). Non-HLA…

Experience of cosmonauts’ health monitoring shows that in the study of healthy subjects clinical approach to the evaluation of various…

Anna G. Chernikova

Research methodology and methods used in experiment Mars-500 held at the Institute of Biomedical Problems of the Russian Academy of Sciences in 2009-2011 are considered. 6 volunteers were isolated during 520 days in a sealed ground-based facility simulating space ship.

In order to evaluate the vegetative regulation of blood circulation and assess individual health risks under conditions of the 520 day isolation, used was an analysis of the heart rate variability (HRV). The most significant changes in the HRV values against the background data were reported in the second half of the said experiment.

The Sonocard experiment purpose was a noninvasive physiological signal recording from sleeping humans. In 2007-2012 the experiment was made by 22 Russian members of 17 missions to the International space station. Of the overall 302 experimental sessions 47 were performed pre, 215 in and 40 after flight.

The article presents the main provisions of the methodology for the analysis of heart rate variability (HRV), which is now actively and widely implemented in many fields of medicine and applied physiology.

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